Tails: Galactic Mission is the video game sequel to the anime, Sonic X. It was released in November 2010 for the Nintendo Wii and Nintendo DS.
The story takes place about six months after Sonic X. Cosmo has sacrificed herself to save the universe and Sonic gives whats left of Cosmo to Tails, a seed. Tails has since then fell into a deep state of depression. Little do they know that Cosmo and the Metarex have survived the Sonic Power Cannon blast. Cosmo is soon captured by Dark Oak and he starts to resurrect his 4 commanders; Red Pine, Yellow Zelkova, Black Narcissus, and Pale Bay Leaf. Tails later recieves a note from Cosmo saying that she's alive, but she's been kidnapped by the Metarex. Tails; with the help of Sonic, Knuckles, Amy Rose, Cream the Rabbit, Shadow, Rouge, Chaotix detectives, Vector, Charmy, and Espio, Silver The Hedgehog, Blaze The Cat and with a twist, Dr. Eggman, must rescue Cosmo from the Metarex. The Metarex are also after the 4 Crystal Seeds and the 7 Planet Eggs. Tails must also prevent the Metarex from getting their hands on the Crystal Seeds and the Planet Eggs in order to rescue Cosmo and once again save the universe.
- Miles "Tails" Prower - The main hero of the game and the first time since the Game Gear game, Tails Adventure. With the help from his friends and Dr. Eggman, he sets out to rescue Cosmo from the Metarex. He also must find the 4 Crystal Seeds and the 7 Planet Eggs before the Metarex do.
- Cosmo the Seedrian - Tails's love interest from the anime Sonic X. She, like the Metarex, survived the Sonic Power Cannon blast during the final battle with Dark Oak and the Metarex. She's the damsel-in-distress that was captured by the Metarex, and Tails must rescue her. This is her first appearence in a Sonic game.
- Sonic the Hedgehog - Tails's best friend. He helps Tails out on his mission to rescue Cosmo, find the Crystal Seeds and the Planet Eggs, and defeat the Metarex.
- Knuckles the Echidna - Tails's other best friend. He helps out for the same reason.
- Amy Rose - Sonic's self-proclaimed girlfriend. Like all the other members of the gang, she helps Tails rescue Cosmo.
- Cream the Rabbit - Amy's best friend, she also assists in trying to rescue Cosmo.
- Shadow the Hedgehog - Sonic's arch-rival but now his best friend who knows so much about Cosmo. He joins the gang to stop Dark Oak and his army. He will also apologize Cosmo for trying to hurt her six months ago after Tails tries to rescue her.
- Rouge the Bat - International jewel thief and Knuckles' arch rival who is Shadow's partner and a government spy for G.U.N. She helps Tails and the gang to rescue Cosmo and prevent the Metarex from the Planet Eggs.
- Dr. Eggman - Sonic's arch enemy who seeks world domination. He also helps rescue Cosmo and restore freedom to the galaxy. He built an all-out interstellar battleship, the Tornado Carrier, where he becomes the group's trusty captain.
- The Metarex - The main villains of the game. They are led by the notorious Dark Oak. They, like Cosmo, survived the Sonic Power Cannon blast during the final battle with Sonic and friends. The Metarex Leader, Dark Oak resurrects his 4 Metarex Commanders; Red Pine, Yellow Zelkova, Black Narcissus, and Pale Bay Leaf. They capture Tails's love intrest, Cosmo, which they succeed in doing. Dark Oak and the Metarex are also after the 4 Crystal Seeds and the 7 Planet Eggs and Tails must stop them from getting their hands on them. Like Cosmo, this is their first appearence in a Sonic game.
- 1 - Verdana
- 2 - Sertez
- 3 - Arcton
- 4 - Vulcanik
- 5 - Funivo
- 6 - Furest
- 7 - Hauntred
- 8 - Metaron
- Tutorial - Green Hill
- Green Plains
- Emerald Forest
- Grand Dunes
- Southern Pyramid
- Snowy Canyon
- Glacier Hill
- Great Ent
- Festive Forest
- Fiery Pass
- Volcanic Cavern
- Casino Palace
- Pinball Highway
- Haunted Base
- Ghost Castle
- Fortress Prison
- Metarex Fortress
- Red Pine
- Yellow Zelkova
- Black Narcissus
- Pale Bay Leaf
- Dark Oak
- Super Tails Vs. The Forestation Planet
The game features a new cast with well-known video game voice actors, including Alyson Court, who is known for voicing Jubilee in X-Men The Animated Series and Claire Redfield in the Resident Evil series, who has apparently replaced Amy Birnbaum as the voice of Cosmo. The rest of the new cast is yet to be confirmed.
- Kate Higgins - Miles "Tails" Prower/Super Tails
- Alyson Court - Cosmo the Seedrian
- Roger Craig Smith - Sonic the Hedgehog
- Travis Willingham - Knuckles The Echidna
- Cindy Robinson - Amy Rose
- Michelle Ruff - Cream The Rabbit
- Kirk Thornton - Shadow The Hedgehog, Orbot
- Karen Strassman - Rouge The Bat
- Quinton Flynn - Silver The Hedgehog
- Laura Bailey - Blaze The Cat
- Kieth Silverstien - Vector The Crocodile
- Colleen Villard - Charmy Bee
- Troy Baker - Espio The Chameleon
- Wally Wingert as Cubot
- Mike Pollock - Doctor Eggman
- Matt Sloan[From Star Wars] - Dark Oak
- Mark Hamill - Black Narcissus
- Roger L. Jackson - Red Pine
- Corey Burton - Pale Bay Leaf
- David Kaye - Yellow Zelkova